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Planta Med. 2002 Dec;68(12):1059-62.

Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex.

Author information

1
Department of Natural Product Chemistry, Shenyang Pharmaceutical University, P.R.China. syliu@mail.sy.In.cn

Abstract

Twenty-six flavonoids were isolated from Scutellaria baicalensis. Their affinities for the benzodiazepine (BDZ) binding site of GABA A receptor have been studied using [ 3H]flunitrazepam binding to rat cortical membranes in vitro. The structure-activity relationships suggested that 2'-OH flavones exhibited the most potent binding affinity, which could lead to the design and discovery of new BDZ receptor ligands.

PMID:
12494329
DOI:
10.1055/s-2002-36357
[Indexed for MEDLINE]

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