Format

Send to

Choose Destination
Clin Biochem. 2002 Oct;35(7):565-7.

Urinary free light chain analysis by the Freelite immunoassay: a preliminary study in multiple myeloma.

Author information

1
Laboratoire de Biochimie A, Hôpital St-Louis AP-HP, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France. thierry.le-bricon@sls.ap-hop-paris.fr

Abstract

Evaluate the Freelite free light chain immunoassay for urine analysis in myeloma. Urine specimens from 20 patients were analyzed by Freelite (The Binding Site) and SDS-agarose gel electrophoresis (Hydragel protéinurie, Sebia). Using the kappa/lambda ratio, Freelite was more sensitive than electrophoresis to detect free light chains, but concentration was overestimated in 75% of cases. Despite high sensitivity and full automation, Freelite inaccurately measures monoclonal free light chains in urine.

PMID:
12493586
DOI:
10.1016/s0009-9120(02)00386-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center