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Trends Genet. 2003 Jan;19(1):39-46.

RNA interference: traveling in the cell and gaining functions?

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School of Biological Sciences and Plant Science Initiative, University of Nebraska-Lincoln, E211 Beadle Center, Post Office Box 880666, Lincoln, NE 68588-0666, USA.


Double-stranded RNA can induce the degradation of homologous RNAs in organisms as diverse as protozoa, animals, plants and fungi, resulting in post-transcriptional gene silencing. But in some species, RNA-mediated processes can also lead to translational repression, DNA methylation, heterochromatin formation or DNA elimination. In some situations, amplification of the 'trigger' double-stranded RNA seems to be required for efficient silencing. These findings imply that RNA-mediated mechanisms can control gene expression at both the transcriptional and the post-transcriptional level, and that they can operate in the nuclear and the cytoplasmic compartments.

[Indexed for MEDLINE]

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