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Clin Infect Dis. 2003 Jan 1;36(1):120-3. Epub 2002 Dec 12.

Human herpesvirus 6B infection of the large intestine of patients with diarrhea.

Author information

1
Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan. kiyokoamo@pop12.odn.ne.jp

Abstract

Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.

PMID:
12491213
DOI:
10.1086/345464
[Indexed for MEDLINE]

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