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J Comput Aided Mol Des. 2002 May-Jun;16(5-6):415-30.

Exploring privileged structures: the combinatorial synthesis of cyclic peptides.

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Institute for Molecular Bioscience, The University of Queensland, St. Lucia, 4072, Qld., Australia.


Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.

[Indexed for MEDLINE]

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