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J Mass Spectrom. 2002 Dec;37(12):1185-98.

Gene expression profiling using advanced mass spectrometric approaches.

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Environmental Molecular Sciences Laboratory, MSIN: K8-98, Pacific Northwest National Laboratory, PO Box 999, Richland, Washington 99352, USA.


In the era of systems biology, computational and high-throughput experimental biological approaches are increasingly being combined to provide global snapshots of entire genomes and proteomes under tissue- and disease-specific conditions. The aim is to identify proteins changing in concentration and/or post-translational state and/or location, and develop a better molecular level understanding of the operation of biological systems. Here we describe an approach for comparative proteomics that builds upon the combination of high-performance nano-scale separations with the high-mass measurement accuracy, mass-resolving power and sensitivity of Fourier transform ion cyclotron resonance mass spectrometry to provide broad dynamic range, comprehensive and quantitative proteome measurements.

[Indexed for MEDLINE]

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