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Neuroreport. 2002 Dec 3;13(17):2309-12.

Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.

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Institut de Génétique Humaine, CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France.


The Drosophila linotte1 mutation was isolated from a genetic screen designed to identify learning and memory genes. For some authors, this mutation affects a novel gene specifically involved in adult learning and memory, whereas for others, it is an allele of the derailed receptor tyrosine kinase gene (the linotte/derailed gene) involved in nervous system development. Here, we show that the original derailed mutation induces a memory phenotype. We also report that a new null mutation, lioexc21, affecting specifically the linotte/derailed gene causes behavioral defects, which can be partially rescued by expression of a lio+/drl+ transgene. The data presented here suggest that the memory phenotype of linotte and derailed mutants is a consequence of abnormal brain development due to loss of function of the linotte/derailed encoded receptor tyrosine kinase.

[Indexed for MEDLINE]

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