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Heart. 2003 Jan;89(1):36-41.

Cumulative risk assessment in unstable angina: clinical, electrocardiographic, autonomic, and biochemical markers.

Author information

1
Department of Cardiology, Barts and the London NHS Trust, London, UK. srok@dircon.co.uk

Abstract

OBJECTIVES:

To determine the incremental value of clinical data, troponin T, ST segment monitoring, and heart rate variability for predicting outcome in patients with non-ST elevation acute coronary syndromes.

METHODS:

Prospective cohort study of 304 consecutive patients. Baseline clinical and electrocardiographic data were recorded, serial blood samples were obtained for troponin T assay, and 48 hour Holter monitoring was performed for ST segment and heart rate variability analysis. End points were cardiac death and non-fatal myocardial infarction during 12 months' follow up.

RESULTS:

After 12 months, 7 patients had died and 21 had had non-fatal myocardial infarction. The risk of an event was increased by troponin T > 0.1 microg/l, T wave inversion on the presenting ECG, Holter ST shift, and a decrease in the standard deviation of 5 minute mean RR intervals. Positive predictive values of individual multivariate risk were low; however, analysis of all multivariate risk markers permitted calculation of a cumulative risk score, which increased the positive predictive value to 46.9% while retaining a negative predictive value of 96.9%.

CONCLUSION:

A cumulative approach to risk stratification in non-ST elevation coronary syndromes successfully identifies a group in whom the risk of cardiac death or non-fatal myocardial infarction approaches 50%.

PMID:
12482787
PMCID:
PMC1767509
[Indexed for MEDLINE]
Free PMC Article
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