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Curr Opin Biotechnol. 2002 Dec;13(6):593-7.

Antibody discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics.

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1
Abgenix, Inc., 6701 Kaiser Drive, Fremont, CA 94555, USA.

Abstract

Technical advances made in the 1980s and early 1990s resulted in monoclonal antibodies that are now approved for human therapy. Novel transgenic mouse strains provide a powerful technology platform for creating fully human monoclonal antibodies as therapeutics; ten such antibodies have entered clinical trials since 1998 and more are in preclinical testing. Improved transgenic mouse strains provide a powerful technology platform for creating human therapeutics in the future.

PMID:
12482519
[Indexed for MEDLINE]
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