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Curr Opin Biotechnol. 2002 Dec;13(6):572-7.

Screening for novel enzymes for biocatalytic processes: accessing the metagenome as a resource of novel functional sequence space.

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BRAIN Aktiengesellschaft, Darmstaedter Strasse 34, D-64673, Zwingenberg, Germany.


Historically, biotechnology has missed up to 99% of existing microbial resources by using traditional screening techniques. Strategies of directly cloning 'environmental DNA' comprising the genetic blueprints of entire microbial consortia (the so-called 'metagenome') provide molecular sequence space that along with ingenious in vitro evolution technologies will act synergistically to bring a maximum of available sequence-space into biocatalytic application.

[Indexed for MEDLINE]

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