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Bioorg Med Chem Lett. 2003 Jan 20;13(2):265-7.

The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies.

Author information

1
Department of Plant and Microbial Sciences, University of Canterbury, Christchurch, New Zealand.

Abstract

We report two three-step syntheses of (S)-aspartate semi-aldehyde, an important synthetic and biosynthetic precursor, from diprotected aspartic acid. The first synthesis proceeds via a thioester, the second via a Weinreb amide. Each route yields pure (S)-aspartate semi-aldehyde in excellent yield. (S)-Aspartate semi-aldehyde prepared in this manner has proved appropriate as a substrate for detailed enzyme studies.

PMID:
12482436
DOI:
10.1016/s0960-894x(02)00923-x
[Indexed for MEDLINE]

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