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Brain Res. 2003 Jan 3;959(1):169-72.

Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model.

Author information

1
Applied Pharmacology Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. suzuki_m@yamanouchi.co.jp

Abstract

YM872, an AMPA receptor antagonist, was administered together with t-PA to investigate the effects of coadministration on neuroprotection in a rat embolic stroke model, when administered 2 h after embolism. T-PA or YM872 alone decreased infarct volume and improved the neurological deficit score. Coadministration of YM872 and t-PA resulted in a further decrease in infarct volume and improvement of the neurological score as compared with single administration of t-PA. These data demonstrate that coadministration of YM872 and t-PA produces more potent neuroprotective effects than when t-PA is administered alone.

PMID:
12480171
DOI:
10.1016/s0006-8993(02)03759-9
[Indexed for MEDLINE]

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