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Gut. 2003 Jan;52(1):7-8.

HLA-DQ8 as an Ir gene in coeliac disease.

Author information

1
Department of Medicine and Institute of Immunology, Rikshospitalet, N-0027 Oslo, Norway. knut.lundin@rikshospitalet.no

Abstract

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease.

PMID:
12477747
PMCID:
PMC1773536
[Indexed for MEDLINE]
Free PMC Article

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