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Oncogene. 2002 Dec 9;21(56):8643-51.

Studying the pathogenesis of BCR-ABL+ leukemia in mice.

Author information

1
The Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, Massachusetts, MA 02115, USA. vanetten@cbr.med.harvard.edu

Abstract

Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ability to recapitulate precisely the phenotypes of BCR-ABL+ leukemias in vivo, but this comes at the price of significant complexity. Here I review recent studies of leukemias induced in mice by BCR-ABL with an emphasis on the intricate nature of these diseases and the need for careful pathological and molecular analysis.

PMID:
12476310
DOI:
10.1038/sj.onc.1206091
[Indexed for MEDLINE]
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