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Diabetes. 2002 Dec;51 Suppl 3:S385-8.

Intracellular targeting of protein kinases and phosphatases.

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Howard Hughes Medical Institute, Vollum Institute, Portland, Oregon 97201-3098, USA.


Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of actin reorganization events.

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