Format

Send to

Choose Destination
Biochem J. 2003 Feb 15;370(Pt 1):29-34.

Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.

Author information

1
Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S-75124, Sweden.

Abstract

The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.

PMID:
12475393
PMCID:
PMC1223168
DOI:
10.1042/BJ20021539
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center