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Endocrinol Metab Clin North Am. 2002 Dec;31(4):915-25.

Hyperuricosuric calcium nephrolithiasis.

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Division of Urology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C-319, Denver, CO 80262, USA.


Since the findings of YĆ¼ and Gutman [1], the hyperuricosuric calcium stone former is a unique clinical entity. While an impressive number of clinical and epidemiologic studies implicate hyperuricosuria in calcium stone formation, the exact physicochemical mechanism by which uric acid affects calcium oxalate crystallization has not been proven. Allopurinol decreases stone recurrences and is the drug of choice for patients with isolated HCN.

[Indexed for MEDLINE]

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