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Curr Opin Cell Biol. 2002 Dec;14(6):692-9.

Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequences.

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  • 1Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA.


Histone mRNA metabolism is tightly coupled to cell cycle progression and to rates of DNA synthesis. The recent identification of several novel proteins involved in histone gene transcription and pre-mRNA processing has shed light on the variety of mechanisms cells employ to achieve this coupling.

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