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Curr Opin Cell Biol. 2002 Dec;14(6):676-83.

Transcriptional regulatory networks and the yeast cell cycle.

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Department of Molecular Genetics and Microbiology, Life Science Building, University of Stony Brook, Stony Brook, NY 11794-5222, USA.


A large amount of microarray gene expression data relevant to the yeast cell cycle has been collected, and several hundred genes have been placed into a model transcriptional control network. Genome-wide studies of the location of cell cycle transcription factors, and a variety of computational approaches, have allowed refinement of the model, and at the same time show how other genome-wide data sets may be organised into model networks.

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