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Science. 2002 Dec 20;298(5602):2398-401. Epub 2002 Dec 5.

Rates of behavior and aging specified by mitochondrial function during development.

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1
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.

Abstract

To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.

PMID:
12471266
DOI:
10.1126/science.1077780
[Indexed for MEDLINE]
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