Format

Send to

Choose Destination
See comment in PubMed Commons below
Reprod Biomed Online. 2002;4 Suppl 3:14-7.

Implantation and immunology: maternal inflammatory and immune cellular responses to implantation and trophoblast invasion.

Author information

1
Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. Robert.Pijnenborg@uz.kuleuven.ac.be

Abstract

Implantation and placentation present an immune challenge because of the semi-allogeneic nature of the conceptus. In this review, histological evidence for maternal immune cellular responses at the implantation site is summarized. Decidualization of the endometrium itself has features in common with an inflammatory response. During decidualization, infiltration by uterine natural killer (NK) cells occurs, and these interact with the non-polymorphic human leukocyte antigen (HLA) class I antigens expressed by invading extravillous trophoblasts. In humans, extension of trophoblast invasion beyond the decidual layer into the myometrium presents an additional challenge, which might be relevant for pregnancy complications such as pre-eclampsia. How far maternal cellular responses to invading trophoblasts seen at later stages of pregnancy can be traced back to the implantation period is an open question.

PMID:
12470559
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center