Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2002 Dec;13(6):507-13.

Cardiac development in zebrafish: coordination of form and function.

Author information

Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.


Organogenesis is a dynamic process involving multiple phases of pattern formation and morphogenesis. For example, heart formation involves the specification and differentiation of cardiac precursors, the integration of precursors into a tube, and the remodeling of the embryonic tube to create a fully functional organ. Recently, the zebrafish has emerged as a powerful model organism for the analysis of cardiac development. In particular, zebrafish mutations have revealed specific genetic requirements for cardiac fate determination, migration, fusion, tube assembly, looping, and remodeling. These processes ensure proper cardiac function; likewise, cardiac function may influence aspects of cardiac morphogenesis.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center