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Eur J Cardiothorac Surg. 2002 Dec;22(6):1014-6.

Gastrointestinal stromal tumor of the posterior mediastinum.

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Veterans Affairs Medical Center, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA.


Gastrointestinal stromal tumor (GIST) is a rare, but potentially aggressive tumor. We present an asymptomatic 64-year-old man with an incidental 9-cm GIST that arose in the posterior mediastinum. Wide surgical excision was performed with rotation of an intercostal muscle flap to buttress a surgically created esophageal wall defect. The patient is now free of disease 26 months postoperative. This tumor is defined by the carcinogenic over-expression of KIT-protein, a tyrosine kinase receptor. Accurate diagnosis of gastrointestinal stromal tumor is imperative, as specific medical therapy is now available for potential control of recurrent or metastatic disease.

[Indexed for MEDLINE]

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