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Bioorg Med Chem Lett. 2003 Jan 6;13(1):125-8.

Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands.

Author information

1
Discovery Chemistry-Wilmington, Bristol-Myers Squibb Company, Experimental Station, DE 19880, USA. argyrios.arvanitis@bms.com

Abstract

A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmacokinetic model to assess plasma levels at 1mg/kg (po) and in the rat situational anxiety model to assess anxiolytic efficacy at 3mg/kg (po). The structure-activity relationships for good receptor binding affinity are described herein.

PMID:
12467631
DOI:
10.1016/s0960-894x(02)00833-8
[Indexed for MEDLINE]

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