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Expert Rev Mol Diagn. 2002 Nov;2(6):616-24.

PCR for the diagnosis of toxoplasmosis after hematopoietic stem cell transplantation.

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Washington University, Department of Pathology and Immunology, 660 S. Euclid Ave., Box 8118, St. Louis, MO 63110, USA.


Toxoplasma gondii is a ubiquitous pathogen that causes significant morbidity and mortality in immunocompromised patients. Although relatively uncommon, toxoplasmosis is increasingly recognized as a severe complication of hematopoietic stem cell transplantation. Timely and accurate diagnosis of this treatable infection is critical. PCR-based testing has become the preferred method for diagnosis, occasionally replacing tissue biopsy. This article reviews the clinical, diagnostic and therapeutic aspects of toxoplasmosis in the setting of hematopoietic stem cell transplantation and the current and future role of PCR-based testing for early detection and diagnosis.

[Indexed for MEDLINE]

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