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Curr Opin Struct Biol. 2002 Oct;12(5):616-23.

Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions.

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Departments of Molecular Pharmacology, Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.


Multivalent protein-carbohydrate interactions regulate essential cellular events, including cell proliferation, adhesion and death. These multivalent interactions can create homogeneous complexes of lectins, such as the galectins, with their saccharide ligands. Lectin-saccharide complexes can concentrate specific glycoproteins or glycolipids within the lattice, while excluding other cell surface molecules. The formation of lectin-saccharide lattices on the cell surface can thus organize the plasma membrane into specialized domains that perform unique functions.

[Indexed for MEDLINE]

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