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Cell. 2002 Nov 27;111(5):607-10.

How to flip the (redox) switch.

Author information

1
Department of Chemical Engineering, Institute for Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA. georgiou@che.utexas.edu

Abstract

Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways.

PMID:
12464172
DOI:
10.1016/s0092-8674(02)01165-0
[Indexed for MEDLINE]
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