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Can J Neurol Sci. 2002 Nov;29(4):375-7.

Brain metastasis from prostate small cell carcinoma: not to be neglected.

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1
Department of Neurosurgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

Abstract

BACKGROUND:

Symptomatic brain metastases from prostatic carcinoma are rare (0.05% to 0.5%).

CASE REPORT:

A 70-year-old man presented with a homonymous hemianopsia due to brain metastatic prostatic carcinoma shortly before becoming symptomatic of prostatic disease. CT and MRI of the brain showed a tumour deep in the right hemisphere near the thalamus and involving the optic radiation.

RESULTS:

Routine haematological and biochemical tests were normal. The prostate specific antigen level was low on two separate occasions. The prostatic and brain tumours showed identical appearances, namely of a poorly differentiated adenocarcinoma with neuroendocrine differentiation (small cell carcinoma).

CONCLUSION:

A literature review suggests that small cell carcinoma of the prostate is more likely to spread to the brain compared to adenocarcinoma and that brain metastases indicate a poor prognosis. The prostate gland should be remembered as a possible cause of brain metastases and that a normal serum prostate specific antigen does not exclude this diagnosis.

PMID:
12463494
[Indexed for MEDLINE]
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