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Eur J Clin Microbiol Infect Dis. 2002 Nov;21(11):767-74. Epub 2002 Oct 31.

Candidemia at a tertiary-care hospital: epidemiology, treatment, clinical outcome and risk factors for death.

Author information

1
Department of Medicine, Division of Infectious Diseases, The University of Texas, Health Science Center at San Antonio, USA. angelviudes@hotmail.com

Abstract

The demographic, clinical and microbiological data of patients with candidemia at the "Hopital Universitario La Fe", a tertiary-care hospital in Valencia, Spain, from 1995 to 1997 was analyzed retrospectively. Candida spp. were isolated in blood cultures from 145 patients, 32% of whom were children (25% of these were neonates). The most common species isolated was Candida albicans, followed by Candida parapsilosis, Candida krusei and Candida tropicalis. Risk factors for candidemia included underlying disease, therapy with broad-spectrum antibiotics and the presence of a central venous catheter. The majority of children were treated with amphotericin B, whereas 52% of adults received fluconazole. Overall mortality was 44% (30% in children and 50% in adults), and attributable mortality was 30% (24% in children and 33% in adults). Multivariate analysis indicated that neutropenia, corticosteroid therapy, lack of antifungal treatment, and failure to replace the central venous catheter were factors associated with candidemia-related death. Among the adult population, an APACHE II score greater than 15 predicted candidemia-related death.

PMID:
12461585
DOI:
10.1007/s10096-002-0822-1
[Indexed for MEDLINE]

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