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Nat Rev Mol Cell Biol. 2002 Dec;3(12):957-64. doi: 10.1038/nrm971.

How do microtubules guide migrating cells?

Abstract

Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.

PMID:
12461561
DOI:
10.1038/nrm971
[Indexed for MEDLINE]

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