Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2002 Dec;3(12):932-43.

uPAR: a versatile signalling orchestrator.

Author information

1
Department of Molecular Biology and Functional Genomics, DIBIT, Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy. blasi.francesco@lsr.it

Abstract

The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.

PMID:
12461559
DOI:
10.1038/nrm977
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center