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Curr Opin Biotechnol. 2002 Oct;13(5):468-72.

Short-term and long-term modulation of gene expression by antisense therapeutics.

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1
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, CB 7295, Chapel Hill, NC 27599-7295, USA.

Abstract

To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNase H degradation of target RNA are needed. In addition to short-term oligonucleotide effects, long-term gene regulation can be accomplished by intracellularly expressed antisense RNAs delivered by viral vectors.

PMID:
12459339
[Indexed for MEDLINE]
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