Send to

Choose Destination
Curr Opin Biotechnol. 2002 Oct;13(5):429-36.

Advances in lentiviral vector design for gene-modification of hematopoietic stem cells.

Author information

Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital Los Angeles, 4650 Sunset Blvd, MS 62, Los Angeles, CA 90027, USA.


Lentiviral vectors are more efficient at transducing quiescent hematopoietic stem cells than murine retroviral vectors. This characteristic is due to multiple karyophilic components of the lentiviral vector pre-integration complex. Lentiviral vectors are also able to carry more complex payloads than murine retroviral vectors, making it possible to deliver expression cassettes that direct either constitutive or targeted expression in various hematopoietic stem cell progeny.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center