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Curr Opin Biotechnol. 2002 Oct;13(5):418-23.

Production of clinical-grade recombinant adeno-associated virus vectors.

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1
Powell Gene Therapy Center, University of Florida Genetics Institute, Department of Pediatrics, 1600 SW Archer Road, Gainesville, FL 32610-0266, USA.

Abstract

Recombinant adeno-associated viral (rAAV) vectors are being evaluated in animal models and humans. Pre-clinical data demonstrating vector safety, efficiency and efficacy have been used to initiate human clinical trials. The clinical manufacture of rAAV vectors has supported phase I and phase II trials, showing that adeno-associated virus serotype 2 vectors are safe when administered to humans.

PMID:
12459331
[Indexed for MEDLINE]
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