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J Med Chem. 2002 Dec 5;45(25):5604-6.

Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.

Author information

1
Organic Chemistry Department, Southern Research Institute, P.O. Box 55305, Birmingham, Alabama 35255-5305, USA.

Abstract

A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).

PMID:
12459027
DOI:
10.1021/jm020310n
[Indexed for MEDLINE]

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