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Int J Colorectal Dis. 2003 Jan;18(1):33-5. Epub 2002 Jun 14.

Course and follow-up of solitary Peutz-Jeghers polyps: a case series.

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1
Department of Colorectal Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Abstract

BACKGROUND AND AIMS:

Peutz-Jeghers syndrome (PJS) is a rare, autosomal-dominant disease characterized by hamartomatous polyps of the alimentary tract, hyperpigmentation of the skin, and family history of PJS. Rarely, solitary Peutz-Jeghers polyps (PJP) arise in patients without other features of PJS.

PATIENTS AND METHODS:

We reviewed eight patients since 1979 with solitary PJP, six men and two women.

RESULTS:

The average age at diagnosis was higher (56+/-13 years) than that of PJS patients in the literature. Polyps were found in the sigmoid colon ( n=4), cecum ( n=1), stomach ( n=1), and duodenum ( n=2). The colonic polyps were diagnosed and removed endoscopically. Indications for colonoscopy included routine screening ( n=4) or rectal bleeding ( n=1). The duodenal and gastric polyps were diagnosed and removed during gastroduodenoscopic examinations, which were performed for nonspecific dyspepsia ( n=2) or gastrointestinal bleeding ( n=1). The median size was 20 mm (range 2 mm-25 mm). Patients were followed for a median of 11.5 years (range 3-22) without another PJP or cancer. Three patients died of causes unrelated to PJP. Five patients are alive and polyp free.

CONCLUSION:

Solitary PJP do not carry a risk of gastrointestinal cancer and are not an indication for specific high-risk screening.

PMID:
12458378
DOI:
10.1007/s00384-002-0411-x
[Indexed for MEDLINE]
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