Developments in RNA chemistry, a personal view

Biochimie. 2002 Sep;84(9):841-8. doi: 10.1016/s0300-9084(02)01459-1.

Abstract

This review describes some of the contributions of chemistry to the RNA field with a personal bias towards the phosphorothioate modification and the derivatives at the ribose 2'-position. The usefulness of these modifications is discussed and documented with some examples.

Publication types

  • Review

MeSH terms

  • Animals
  • Metals / chemistry
  • Metals / metabolism
  • Nucleosides / chemistry
  • Nucleosides / metabolism
  • Phosphates / chemistry
  • Phosphates / metabolism
  • RNA / chemistry*
  • RNA / metabolism
  • RNA, Catalytic / chemistry*
  • RNA, Catalytic / metabolism
  • Stereoisomerism
  • Thionucleotides / chemistry*
  • Thionucleotides / metabolism

Substances

  • Metals
  • Nucleosides
  • Phosphates
  • RNA, Catalytic
  • Thionucleotides
  • RNA