Abstract
This review describes some of the contributions of chemistry to the RNA field with a personal bias towards the phosphorothioate modification and the derivatives at the ribose 2'-position. The usefulness of these modifications is discussed and documented with some examples.
MeSH terms
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Animals
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Metals / chemistry
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Metals / metabolism
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Nucleosides / chemistry
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Nucleosides / metabolism
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Phosphates / chemistry
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Phosphates / metabolism
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RNA / chemistry*
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RNA / metabolism
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RNA, Catalytic / chemistry*
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RNA, Catalytic / metabolism
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Stereoisomerism
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Thionucleotides / chemistry*
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Thionucleotides / metabolism
Substances
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Metals
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Nucleosides
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Phosphates
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RNA, Catalytic
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Thionucleotides
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RNA