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Trends Pharmacol Sci. 2002 Dec;23(12):576-82.

Recent advances in angiogenesis, anti-angiogenesis and vascular targeting.

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INSERM E 0113 Molecular Mechanisms of Angiogenesis and Growth Factor and Cell Differentiation Laboratory, University Bordeaux I, France.


Angiogenesis, the development of new blood vessels, has become a major focus of research. This has been stimulated by the therapeutic opportunities offered by the ability to manipulate the vasculature in pathologies such as cancer. Here, we present an overview of recent advances in angiogenesis. Especially noteworthy is the large volume of information from developmental studies, particularly those that involve transgenic and gene knockout mice. We also discuss the increasing repertoire of drugs with which to manipulate angiogenesis and new endothelial-specific genes with which to target the vasculature.

[Indexed for MEDLINE]

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