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Semin Immunol. 2002 Dec;14(6):423-30.

Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection.

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Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Department of Immunology, University of Toronto, 610 University Avenue, 7-504 Toronto, Ont., Canada M5G 2M9.


Hematopoiesis is regulated by a variety of signals that either originate within a developing cell or are supplied by the surrounding environment in secreted- or contact-dependent forms. This review discusses the effects of one secreted factor, interleukin-7, on the development of B lymphocytes. We describe a molecular mechanism for a crucial checkpoint during B lineage maturation, based on the integration of signals mediated by the pre-B cell receptor, the interleukin-7 receptor, and the environment in which these signals are received.

[Indexed for MEDLINE]

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