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J Neural Transm Suppl. 2002;(62):303-7.

Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease--a target for neuroprotective treatment strategies?

Author information

1
Neuroimmunological Cell Biology, Interdisciplinary Center of Clinical Research (IZKF), Leipzig, Federal Republic of Germany. mueg@medizin.uni-leipzig.de

Abstract

Accumulation of Advanced Glycation Endproducts (AGEs) in the brain is a feature of ageing and degeneration, especially in Alzheimer's disease (AD). Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (beta-amyloid and MAP-tau), glial activation, oxidative stress and neuronal cell death. Oxidative stress and AGEs initiate a positive feedback loop, where normal age-related changes develop into a pathophysiological cascade. Combined intervention using antioxidants, anti-inflammatory drugs and AGE-inhibitors may be a promising neuroprotective strategy.

PMID:
12456073
[Indexed for MEDLINE]

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