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Phys Med Biol. 2002 Nov 7;47(21):3789-95.

Label-free bioaffinity detection using terahertz technology.

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  • 1Center for Terahertz Research, Department of Physics, Applied Physics & Astronomy, Rensselaer Polytechnic Institute, NY 12180, USA.


We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 microg cm(-2) of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.

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