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Cancer Cell. 2002 Nov;2(5):351-2.

Switching from life to death: the Miz-ing link between Myc and p53.

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Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Galsgow G61 1BD, UK.


Cells can respond to the activation of the tumor suppressor protein p53 by undergoing cell cycle arrest or apoptosis, and Myc has now been shown to help switch the response to apoptosis by repressing the expression of p21(CIP1), a cyclin-dependent kinase inhibitor with antiapoptotic activity.

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