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Biosci Biotechnol Biochem. 2002 Oct;66(10):2221-3.

Inhibition by ajoene of skin-tumor promotion in mice.

Author information

1
Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd., 310 Nakasuna-cho, Tempaku-ku, Nagoya, Aichi 468-0065, Japan.

Abstract

Ajoene, a major compound containing sulfur in oil-macerated garlic products, inhibited in a two-stage carcinogenesis test on mouse skin. Treatment with ajoene suppressed skin tumor formation, depending on the amount. In particular, the group treated with 250 microg of ajoene had only 4.9% the number of tumors per mouse compared with the control group at 18 weeks.

PMID:
12450136
DOI:
10.1271/bbb.66.2221
[Indexed for MEDLINE]
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