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Ann Neurol. 2002 Dec;52(6):832-6.

Loss of myostatin attenuates severity of muscular dystrophy in mdx mice.

Author information

1
Department of Neurology, The Johns Hopkins University, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

Abstract

Myostatin, a transforming growth factor-beta family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.

PMID:
12447939
DOI:
10.1002/ana.10385
[Indexed for MEDLINE]

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