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J Infect Dis. 2002 Dec 15;186(12):1857-60. Epub 2002 Nov 14.

Association between Helicobacter pylori infection and increased risk of typhoid fever.

Author information

1
Advanced Center for Diarrheal Disease Research, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. community.research@cih.uib.no

Abstract

Helicobacter pylori infection has been reported to increase the risk of cholera. This nested case-control study was conducted to determine whether H. pylori infection is associated with occurrence of typhoid fever. Eighty-three case subjects of culture-proven typhoid fever were identified through a 1-year surveillance of subjects aged 0-40 years in an urban slum. Two age- and sex-matched neighborhood control subjects were concurrently selected for each case subject. Serum anti-H. pylori immunoglobulin G antibodies were measured in case and neighborhood control subjects. For determining other risk factors, 2 additional community control subjects per case were selected. There was a significant association between the presence of serum anti-H. pylori immunoglobulin G antibodies and typhoid fever (adjusted odds ratio, 2.03; 95% confidence interval, 1.02-4.01). Illiteracy, being part of a nuclear family, nonuse of soap, and consumption of ice cream were also associated with a significantly greater risk of typhoid fever. This study provides the first empiric evidence that H. pylori infection is associated with an increased risk of typhoid fever.

PMID:
12447776
DOI:
10.1086/345762
[Indexed for MEDLINE]

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