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Bull Exp Biol Med. 2002 Jun;133(6):568-70.

Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases.

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1
Department of General Pathology and Pathophysiology, Russian Medical Academy of Postgraduate Education, Russian Ministry of Health, Moscow. ipomytkin@mtu-net.ru

Abstract

We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H(2)O(2)that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H(2)O(2)and inactivation of liver protein tyrosine phosphatases.

PMID:
12447467
[Indexed for MEDLINE]
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