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Curr Biol. 2002 Nov 19;12(22):R776-8.

Hox proteins: sculpting body parts by activating localized cell death.

Author information

1
Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK. cra21@hermes.cam.ac.uk

Abstract

Hox proteins shape animal structures by eliciting different developmental programs along the anteroposterior body axis. A recent study reveals that the Drosophila Hox protein Deformed directly activates the cell-death-promoting gene reaper to maintain the boundaries between distinct head segments.

PMID:
12445403
DOI:
10.1016/s0960-9822(02)01291-5
[Indexed for MEDLINE]
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