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Curr Biol. 2002 Nov 19;12(22):R776-8.

Hox proteins: sculpting body parts by activating localized cell death.

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  • 1Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK.


Hox proteins shape animal structures by eliciting different developmental programs along the anteroposterior body axis. A recent study reveals that the Drosophila Hox protein Deformed directly activates the cell-death-promoting gene reaper to maintain the boundaries between distinct head segments.

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