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Immunol Rev. 2002 Nov;189:123-35.

Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation.

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Unité de Biologie des Interactions Cellulaires, CNRS URA 1960, Paris, France.


Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.

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