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Bioorg Med Chem Lett. 2002 Dec 16;12(24):3583-6.

Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.

Author information

1
Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vass. Constantinou, Athens 116-35, Greece.

Abstract

1',1'-Cyclopropyl side chain substituents enhance the affinities of Delta(8)-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1',1'-cyclopropyl analogues are described.

PMID:
12443781
DOI:
10.1016/s0960-894x(02)00785-0
[Indexed for MEDLINE]

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